Biomechanical Analysis of Age-Dependent Changes in Fontan Power Loss

A Sahni; L Marshall; M A Cetatoiu; J Davee; N Schulz; E R Eickhoff; N St Clair; S Ghelani; A Prakash; P E Hammer; D M Hoganson; P J Del Nido; R H Rathod; Vijay Govindarajan

doi:10.1007/s10439-024-03534-9

Biomechanical Analysis of Age-Dependent Changes in Fontan Power Loss

Ann Biomed Eng. 2024 May 16. doi: 10.1007/s10439-024-03534-9. Online ahead of print.

Authors

A Sahni¹, L Marshall¹, M A Cetatoiu¹, J Davee¹, N Schulz¹, E R Eickhoff¹, N St Clair¹, S Ghelani^{2

3}, A Prakash^{2

3}, P E Hammer^{1

4}, D M Hoganson^{1

4}, P J Del Nido^{1

4}, R H Rathod^{2

3}, Vijay Govindarajan^{5

6

7}

Affiliations

¹ Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
² Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
³ Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
⁴ Department of Surgery, Harvard Medical School, Boston, MA, USA.
⁵ Department of Cardiac Surgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA. vijay.govindarajan@childrens.harvard.edu.
⁶ Department of Surgery, Harvard Medical School, Boston, MA, USA. vijay.govindarajan@childrens.harvard.edu.
⁷ Department of Internal Medicine (Cardiology), The University of Texas Health Science Center at Houston, Houston, TX, USA. vijay.govindarajan@childrens.harvard.edu.

PMID: 38753109
DOI: 10.1007/s10439-024-03534-9

Abstract

The hemodynamics in Fontan patients with single ventricles rely on favorable flow and energetics, especially in the absence of a subpulmonary ventricle. Age-related changes in energetics for extracardiac and lateral tunnel Fontan procedures are not well understood. Vorticity (VOR) and viscous dissipation rate (VDR) are two descriptors that can provide insights into flow dynamics and dissipative areas in Fontan pathways, potentially contributing to power loss. This study examined power loss and its correlation with spatio-temporal flow descriptors (vorticity and VDR). Data from 414 Fontan patients were used to establish a relationship between the superior vena cava (SVC) to inferior vena cava (IVC) flow ratio and age. Computational flow modeling was conducted for both extracardiac conduits (ECC, n = 16) and lateral tunnels (LT, n = 25) at different caval inflow ratios of 2, 1, and 0.5 that corresponded with ages 3, 8, and 15+. In both cohorts, vorticity and VDR correlated well with PL, but ECC cohort exhibited a slightly stronger correlation for PL-VOR (>0.83) and PL-VDR (>0.89) than that for LT cohort (>0.76 and > 0.77, respectively) at all ages. Our data also suggested that absolute and indexed PL increase (p < 0.02) non-linearly as caval inflow changes with age and are highly patient-specific. Comparison of indexed power loss between our ECC and LT cohort showed that while ECC had a slightly higher median PL for all 3 caval inflow ratio examined (3.3, 8.3, 15.3) as opposed to (2.7, 7.6, 14.8), these differences were statistically non-significant. Lastly, there was a consistent rise in pressure gradient across the TCPC with age-related increase in IVC flows for both ECC and LT Fontan patient cohort. Our study provided hemodynamic insights into Fontan energetics and how they are impacted by age-dependent change in caval inflow. This workflow may help assess the long-term sustainability of the Fontan circulation and inform the design of more efficient Fontan conduits.

Keywords: Age growth; Bulk and indexed power loss; Caval flow ratios; Extracardiac; Lateral tunnel; Non-linearity; Viscous dissipation rate; Fontan hemodynamics; Vorticity.

Grants and funding

R01HL161507/HL/NHLBI NIH HHS/United States