Identification of a novel QTL for lean meat percentage using imputed genotypes

Emil Ibragimov; Anni Øyan Pedersen; Niels Morten Sloth; Merete Fredholm; Peter Karlskov-Mortensen

doi:10.1111/age.13442

Identification of a novel QTL for lean meat percentage using imputed genotypes

Anim Genet. 2024 May 16. doi: 10.1111/age.13442. Online ahead of print.

Authors

Emil Ibragimov¹, Anni Øyan Pedersen¹, Niels Morten Sloth², Merete Fredholm¹, Peter Karlskov-Mortensen¹

Affiliations

¹ Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
² SEGES Danish Pig Research Center, Aarhus, Denmark.

PMID: 38752377
DOI: 10.1111/age.13442

Abstract

Lean meat percentage is a critical production trait in pig breeding systems with direct implications for the sustainability of the industry. In this study, we conducted a genome-wide association study for lean meat percentage using a cohort of 850 Duroc × (Landrace × Yorkshire) crossbred pigs and we identified QTL on SSC3 and SSC18. Based on the predicted effect of imputed variants and using the PigGTEx database of molecular QTL, we prioritized candidate genes and SNPs located within the QTL regions, which may be involved in the regulation of porcine leanness. Our results indicate that a nonsense mutation in ZC3HAV1L on SSC18 has a direct effect on lean meat percentage.

Keywords: QTL; crossbred pigs; lean meat percentage; sustainability.

Abstract

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