Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

Jun Luo; Mingxuan Zhu; Long Zhao; Meiwen He; Bei Li; Yifan Liu; Yuhan Sun; Guoqing Lyu; Zhanlong Shen

doi:10.21147/j.issn.1000-9604.2024.02.09

Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

Chin J Cancer Res. 2024 Apr 30;36(2):226-232. doi: 10.21147/j.issn.1000-9604.2024.02.09.

Authors

Jun Luo¹, Mingxuan Zhu², Long Zhao², Meiwen He¹, Bei Li¹, Yifan Liu³, Yuhan Sun³, Guoqing Lyu¹, Zhanlong Shen²

Affiliations

¹ Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
² Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing 100044, China.
³ School of Medicine, the Chinese University of Hong Kong, Shenzhen 518172, China.

PMID: 38751434
PMCID: PMC11090793
DOI: 10.21147/j.issn.1000-9604.2024.02.09

Abstract

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse. Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function. However, there is currently no consensus on the specific distance of distal resection margin.

Keywords: Colorectal cancer; distal resection margin; neoadjuvant therapy.