Immunity by AS03ation: The natural adjuvantage

Lena Hansen; Jenna J Guthmiller

doi:10.1016/j.immuni.2024.04.011

Immunity by AS03ation: The natural adjuvantage

Immunity. 2024 May 14;57(5):927-929. doi: 10.1016/j.immuni.2024.04.011.

Authors

Lena Hansen¹, Jenna J Guthmiller²

Affiliations

¹ Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
² Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: jenna.guthmiller@cuanschutz.edu.

PMID: 38749392
DOI: 10.1016/j.immuni.2024.04.011

Abstract

Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.

MeSH terms

Adjuvants, Immunologic
Adjuvants, Vaccine
Animals
Antibodies, Viral / immunology
Humans
Immunity, Humoral
Immunity, Innate* / immunology
Influenza Vaccines* / immunology
Influenza, Human / immunology
Influenza, Human / prevention & control
Vaccination