An experimental and theoretical study on mechanistic insights into urolithin-based ratiometric fluorescent probe for instant quantitative detection of fluoride ions

Yuanyue Wang; ChuChu Yang; Xiaoqing Feng; Yanying Zhao

doi:10.1016/j.talanta.2024.126220

An experimental and theoretical study on mechanistic insights into urolithin-based ratiometric fluorescent probe for instant quantitative detection of fluoride ions

Talanta. 2024 May 9:276:126220. doi: 10.1016/j.talanta.2024.126220. Online ahead of print.

Authors

Yuanyue Wang¹, ChuChu Yang¹, Xiaoqing Feng², Yanying Zhao³

Affiliations

¹ School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
² School of Pharmacy & School of Medicine, Changzhou University, Changzhou, 213164, China.
³ School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Electronic address: yyzhao@zstu.edu.cn.

PMID: 38749162
DOI: 10.1016/j.talanta.2024.126220

Abstract

Fluoride detection has been playing an important role in chemical, biological, and medicinal field, especially for keeping physical health and resisting environmental pollution. Herein, a urolithin B fluorescent probe has been successfully developed with good sensitivity, selectivity, anti-interference ability. The low limit of detection (LOD) refers to 0.156 μM, and the instant response time to F^- is less than 1 s. The probe is suitable for quantitatively and qualitatively ratiometric detection for F^- in solution with two distinct emission bands at 425 (blue) and 566 nm (orange), with the coordinate change of CIE from (0.38, 0.41) to (0.22, 0.11). Urolithin B displayed a remarkable ratiometric fluorescence response towards F^-. The detection mechanistic was further proposed by NMR and electronic spectroscopic experiments combining with time-dependent density functional theoretical calculation.

Keywords: Fluoride anion; Instant detection; LOD; Ratiometric fluorescence; TD-DFT; Urolithin.