Prognostic Value of Sublingual Microcirculation in Sepsis: A Systematic Review and Meta-analysis

Aling Tang; Yi Shi; Qingqing Dong; Sihui Wang; Yao Ge; Chenyan Wang; Zhimin Gong; Weizhen Zhang; Wei Chen

doi:10.1177/08850666241253800

Prognostic Value of Sublingual Microcirculation in Sepsis: A Systematic Review and Meta-analysis

J Intensive Care Med. 2024 May 15:8850666241253800. doi: 10.1177/08850666241253800. Online ahead of print.

Authors

Aling Tang¹, Yi Shi¹, Qingqing Dong¹, Sihui Wang¹, Yao Ge¹, Chenyan Wang¹, Zhimin Gong¹, Weizhen Zhang¹, Wei Chen¹

Affiliation

¹ Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

PMID: 38748542
DOI: 10.1177/08850666241253800

Abstract

Objectives: To investigate the relationship between sublingual microcirculation and the prognosis of sepsis. Data sources: The PubMed, Web of Science, Embase, and China National Knowledge Infrastructure (CNKI) databases were searched to identify studies published from January 2003 to November 2023. Study selection: Clinical studies examining sublingual microcirculation and the prognosis of sepsis were included. Data extraction: Sublingual microcirculation indices included the microvascular blood index (MFI), total vascular density (TVD), perfusion vascular density (PVD), perfusion vascular vessel (PPV), and heterogeneity index (HI). Prognostic outcomes included mortality and severity. Funnel plots and Egger's test were used to detect publication bias. The ability of the small vessel PPV (PPVs) to predict sepsis-related mortality was analyzed based on the summary receiver operating characteristic (SROC) curve, pooled sensitivity, and pooled specificity. Data synthesis: Twenty-five studies involving 1750 subjects were included. The TVD (95% CI 0.11-0.39), PVD (95% CI 0.42-0.88), PPV (95% CI 6.63-13.83), and MFI (95% CI 0.13-0.6) of the survival group were greater than those of the nonsurvival group. The HI in the survival group was lower than that in the nonsurvival group (95% CI -0.49 to -0.03). The TVD (95% CI 0.41-0.83), PVD (95% CI 0.83-1.17), PPV (95% CI 14.49-24.9), and MFI (95% CI 0.25-0.66) of the nonsevere group were greater than those of the severe group. Subgroup analysis revealed no significant difference in TVD between the survival group and the nonsurvival group in the small vessel subgroup. The area under the SROC curve (AUC) was 0.88. Conclusions: Sublingual microcirculation was worse among patients who died and patients with severe sepsis than among patients who survived and patients with nonsevere sepsis. PPV has a good predictive value for the mortality of sepsis patients. This study was recorded in PROSPERO (registration number: CRD42023486349).

Keywords: meta; prognostic; sepsis; sublingual microcirculation.