A Case of Pseudothrombocytopenia due to Pre-Analytical Issues Revealed by the Presence of Fibrin in a Blood Film

Clin Lab. 2024 May 1;70(5). doi: 10.7754/Clin.Lab.2023.231129.

Abstract

Background: Pseudothrombocytopenia (PTCP) can be caused by anticoagulants or pre-analytical issues. The authors present a case of PTCP attributed to pre-analytical issues in a 68-year-old male patient.

Methods: The platelet count results were obtained using both the impedance and fluorescence channels of Sysmex XN-10. The blood film was scanned using both Cellavision DM96 and a microscope.

Results: The flag for PLT-Clumps and the scattergram from the PLT-F channel indicated the presence of platelet aggregation. Fibrin could be observed at the feathered end of the blood film. A diagnosis of PTCP resulting from pre-analytical issues was made.

Conclusions: The presence of fibrin in a blood film is a critical indicator for diagnosing PTCP due to pre-analytical issues.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anticoagulants
  • Blood Platelets
  • Fibrin* / analysis
  • Fibrin* / metabolism
  • Humans
  • Male
  • Platelet Aggregation
  • Platelet Count / methods
  • Thrombocytopenia* / blood
  • Thrombocytopenia* / diagnosis