Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

Bahaa Shaqour; Hiba Natsheh; Naim Kittana; Nidal Jaradat; Murad Abualhasan; Ahmad M Eid; Ruaa Moqady; Aya AbuHijleh; Saja Abu Alsaleem; Shahd Ratrout; Lotte De Wever; Chris Vervaet; Valérie Vanhoorne

doi:10.1021/acsbiomaterials.4c00476

Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

ACS Biomater Sci Eng. 2024 May 15. doi: 10.1021/acsbiomaterials.4c00476. Online ahead of print.

Authors

Bahaa Shaqour^{1

2}, Hiba Natsheh^{2

3}, Naim Kittana^{2

4}, Nidal Jaradat³, Murad Abualhasan³, Ahmad M Eid³, Ruaa Moqady³, Aya AbuHijleh³, Saja Abu Alsaleem³, Shahd Ratrout³, Lotte De Wever⁵, Chris Vervaet⁵, Valérie Vanhoorne⁵

Affiliations

¹ Mechanical and Mechatronics Engineering Department, Faculty of Engineering and Information Technology, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
² Medical and Health Sciences Research Center, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
³ Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
⁴ Department of Biomedical Sciences, An-Najah National University, P.O. Box 7, Nablus P4110257, Palestine.
⁵ Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.

PMID: 38747490
DOI: 10.1021/acsbiomaterials.4c00476

Abstract

This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.

Keywords: 3D printed capsules; delayed release; fused filament fabrication; ketoprofen; pH responsive; personalized medicine; self-nanoemulsifying drug delivery system.