Intelligent algorithm based on deep learning to predict the dosage for anesthesia: A study on prediction of drug efficacy based on deep learning

ZhiGang Hu; GuangJian Pan; XinZheng Wang; KeHan Li

doi:10.1002/hsr2.2113

Intelligent algorithm based on deep learning to predict the dosage for anesthesia: A study on prediction of drug efficacy based on deep learning

Health Sci Rep. 2024 May 14;7(5):e2113. doi: 10.1002/hsr2.2113. eCollection 2024 May.

Authors

ZhiGang Hu¹, GuangJian Pan¹, XinZheng Wang¹, KeHan Li²

Affiliations

¹ Department of Biomedical Engineering Henan University of Science and Technology Luoyang China.
² Department of Anesthesiology The First Affiliated Hospital of Henan University of Science and Technology LuoYang China.

Abstract

Background and aims: Anesthetic drugs play a vital role during surgery, however, due to individual differences and complex physiological mechanisms, the prediction of anesthetic drug dosage has always been a challenging problem. In this study, we propose a model for predicting the dosage of anesthetic drugs based on deep learning to help anesthesiologists better control their dosage during surgical procedures.

Methods: We design a model based on the artificial neural network to predict the dosage of preoperative anesthetic, and use the SELU activation function and the loss function for weighted regularization to solve the problem of unbalanced sample. Moreover, we design a CNN-based model for the prior extraction of intraoperative features by using a 7 × 1 convolution kernel to enhance the receptive field, and combine maximum pooling and average pooling to extract key features while eliminating noise. A predictive model based on the LSTM network is designed to predict the intraoperative dosage of the anesthetic, and the bidirectional propagation-based LSTM network is used to improve the ability to learn the trend of changes in the physiological states of the patient during surgery. An attention module is added before the connection layer to appropriately attend to areas containing prominent features.

Results: The results of experiments showed that the proposed method reduced values of the MAPE to 15.83% and 12.25% compared with the traditional method in predictions of the preoperative and intraoperative doses of the anesthetic, respectively, and increased the values of $R^{2}$ to 0.887 and 0.915, respectively.

Conclusion: The intelligent anesthesia prediction algorithm designed in this study can effectively predict the dosage of anesthetic drugs needed by patients, assist clinical judgment of anesthetic drug dose, and assist the anesthesiologists to ensure the smooth progress of the operation.

Keywords: anesthesia dose prediction; attention mechanism; deep learning.