Impaired sensitivity to thyroid hormones is associated with different grades of hypertension: A multicenter cross-sectional study

Lu Yu; Guangwei Pan; Zhu Li; Lin Li; Shan Gao; Fanfan Liu; Yuanyuan He; Yijia Liu; Yutong Liu; Jia Zhao; Rongrong Yang; Chunquan Yu

doi:10.1016/j.numecd.2023.12.019

Impaired sensitivity to thyroid hormones is associated with different grades of hypertension: A multicenter cross-sectional study

Nutr Metab Cardiovasc Dis. 2023 Dec 30:S0939-4753(23)00513-6. doi: 10.1016/j.numecd.2023.12.019. Online ahead of print.

Authors

Lu Yu¹, Guangwei Pan¹, Zhu Li¹, Lin Li¹, Shan Gao¹, Fanfan Liu¹, Yuanyuan He¹, Yijia Liu¹, Yutong Liu¹, Jia Zhao², Rongrong Yang³, Chunquan Yu⁴

Affiliations

¹ Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China.
² Tianjin Chest Hospital, Tianjin, 300222, China. Electronic address: orange2012@126.com.
³ Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: rongrong0423@hotmail.com.
⁴ Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: ycqtjutcm@foxmail.com.

PMID: 38744581
DOI: 10.1016/j.numecd.2023.12.019

Abstract

Background and aim: Accumulating evidence suggests a potential link between thyroid function with hypertension. However, the research results are limited, and there is no research to explore the relationship between central and peripheral thyroid hormones (THs) sensitivity and different grades of hypertension in patients with coronary heart disease (CHD). This study aims to prove the complex interaction between thyroid system and blood pressure, and provides new ideas for the assessment of hypertension in patients with CHD.

Methods and results: Calculate parameters representing central and peripheral sensitivity to THs. Logistic regression analysis was used to analyze the relationship between central and peripheral THs sensitivity of CHD patients and different grades of hypertension, especially in different ages, sexes, blood glucose levels, smoking, and drinking statuses. Among the 34,310 participants, 19,610 (57.16 %) were diagnosed with hypertension. The risk of hypertension and TSHI (OR: 0.88; 95 % CI: 0.87-0.90; P < 0.001), TT4RI (OR: 0.998; 95 % CI: 0.998-0.999; P < 0.001), TFQI (OR: 0.63; 95 % CI: 0.60-0.67; P < 0.001), PTFQI (OR: 0.63; 95 % CI: 0.59-0.67; P < 0.001) was negatively associated. The risk of hypertension was positively associated with FT3/FT4 (OR: 1.20; 95 % CI: 1.17-1.22; P < 0.001). After stratified analysis, these associations remained significant at different ages, sexes, blood glucose levels, grades of hypertension, smoking, and drinking statuses (P < 0.001).

Conclusions: This study shows that the decrease in central THs sensitivity index and the increase in peripheral THs sensitivity index are associated with a higher risk of hypertension in CHD patients.

Keywords: Coronary heart disease; Different grades of hypertension; Hypertension; Thyroid hormone sensitivity.

Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.