Nanocrystalline cellulose as a reinforcing agent for poly (vinyl alcohol)/ gellan-gum-based composite film for moxifloxacin ocular delivery

Sk Habibullah; Rakesh Swain; Souvik Nandi; Mouli Das; Tanmaya Rout; Biswaranjan Mohanty; Subrata Mallick

doi:10.1016/j.ijbiomac.2024.132302

Nanocrystalline cellulose as a reinforcing agent for poly (vinyl alcohol)/ gellan-gum-based composite film for moxifloxacin ocular delivery

Int J Biol Macromol. 2024 May 12;270(Pt 1):132302. doi: 10.1016/j.ijbiomac.2024.132302. Online ahead of print.

Authors

Sk Habibullah¹, Rakesh Swain¹, Souvik Nandi¹, Mouli Das¹, Tanmaya Rout², Biswaranjan Mohanty³, Subrata Mallick⁴

Affiliations

¹ Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar 751003, Odisha, India.
² Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, 754202 Cuttack, Odisha, India.
³ Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, 754202 Cuttack, Odisha, India. Electronic address: biswaranjanm5@gmail.com.
⁴ Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar 751003, Odisha, India. Electronic address: subratamallick@soa.ac.in.

PMID: 38744357
DOI: 10.1016/j.ijbiomac.2024.132302

Abstract

Nanocrystalline cellulose (NCC) is a star material in drug delivery applications due to its good biocompatibility, large specific surface area, high tensile strength (TS), and high hydrophilicity. Poly(Vinyl Alcohol)/Gellan-gum-based innovative composite film has been prepared using nanocrystalline cellulose (PVA/GG/NCC) as a strengthening agent for ocular delivery of moxifloxacin (MOX) via solvent casting method. Impedance analysis was studied using the capacitive sensing technique for examining new capacitance nature of the nanocomposite MOX film. Antimicrobial properties of films were evaluated using Pseudomonas aeruginosa and Staphylococcus aureus as gram-negative and gram-positive bacteria respectively by disc diffusion technique. XRD revealed the characteristic peak of NCC and the amorphous form of the drug. Sustained in vitro release and enhanced corneal permeation of drug were noticed in the presence of NCC. Polymer matrix enhanced the mechanical properties (tensile strength 22.05 to 28.41 MPa) and impedance behavior (resistance 59.23 to 213.23 Ω) in the film due to the presence of NCC rather than its absence (16.78 MPa and 39.03 Ω respectively). Occurrence of NCC brought about good antimicrobial behavior (both gram-positive and gram-negative) of the film. NCC incorporated poly(vinyl alcohol)/gellan-gum-based composite film exhibited increased mechanical properties and impedance behavior for improved ocular delivery of moxifloxacin.

Keywords: Gellan gum; Moxifloxacin hydrochloride (MOX); Nanocrystalline cellulose (NCC).