Flavonoids and triterpenoids isolated from the ethyl acetate extract of Maytenus quadrangulata leaves

Mariana Guerra de Aguilar; Sandy Veríssimo Morais Quintão; Karen Caroline Camargo; Lucienir Pains Duarte; Laisa Resende Vasconcelos; José Carlos de Magalhães; Grasiely Faria Sousa

doi:10.1002/cbdv.202400636

Flavonoids and triterpenoids isolated from the ethyl acetate extract of Maytenus quadrangulata leaves

Chem Biodivers. 2024 May 14:e202400636. doi: 10.1002/cbdv.202400636. Online ahead of print.

Authors

Mariana Guerra de Aguilar¹, Sandy Veríssimo Morais Quintão², Karen Caroline Camargo², Lucienir Pains Duarte², Laisa Resende Vasconcelos³, José Carlos de Magalhães³, Grasiely Faria Sousa⁴

Affiliations

¹ Federal University of Minas Gerais, Chemistry, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, BRAZIL.
² Federal University of Minas Gerais, Departamento de Química, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, BRAZIL.
³ Federal University of São João del-Rei, Departamento de Química, Biotecnologia e Engenharia de Bioprocessos, Campus Alto Paraopeba, Universidade Federal de São João del-Rei, 36497-899, Ouro Branco, BRAZIL.
⁴ Universidade Federal de Minas Gerais, Instituto de Ciências Exatas/Departamento de Química, Avenida Presidente Antônio Carlos, 6627, 31270-901, Belo Horizonte, BRAZIL.

PMID: 38743846
DOI: 10.1002/cbdv.202400636

Abstract

The new flavonoid 4'-O-methylepigallocatechin 5-O-β-D-glucopyranoside (1), along with four known triterpenes (2-4), a steroid (6), and a flavonoid (7) were isolated from the ethyl acetate extract of Maytenus quadrangulata leaves. The chemical structures of the isolated compounds were determined through analysis of 1D NMR (1H and 13C) spectroscopic data, in addition to 2D NMR and spectrometric (MS) data for compound 1. This is the first report of the isolation of compounds 3-O-β-D-glucosyl-β-sitosterol (6) and 4'-O-methylepigallocatechin (7) from this species. Compounds 1 and 7 were evaluated against the bacteria Staphylococcus aureus and Klebsiella pneumoniae, but neither exhibited activity even at the highest concentration tested.

Keywords: Celastraceae; Maytenus; Maytenus quadrangulata; antibacterial; flavonoid.