Abstract
An unusual rhodium-catalyzed C-H activation/Lossen rearrangement/oxa-Michael addition tandem cyclization has been achieved along with a tunable well-known C-H activation/[4 + 2] annulation, leading to regio-, chemo-, and diastereoselective access to diverse pentacyclic α-carbolines and β-carboline-1-one derivatives in moderate to good yields with significant anticancer activity.
MeSH terms
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Antineoplastic Agents* / chemical synthesis
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / pharmacology
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Carbolines* / chemical synthesis
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Carbolines* / chemistry
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Carbolines* / pharmacology
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Catalysis
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Cyclization
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Rhodium* / chemistry
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Stereoisomerism
Substances
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Rhodium
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Carbolines
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Antineoplastic Agents