Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis

Tannaz Jamialahamdi; Elaheh Mirhadi; Wael Almahmeed; Ali H Eid; Khalid Al-Rasadi; Ninh T Nguyen; Kishore M Gadde; Amirhossein Sahebkar

doi:10.1007/s13304-024-01866-8

Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis

Updates Surg. 2024 May 14. doi: 10.1007/s13304-024-01866-8. Online ahead of print.

Authors

Tannaz Jamialahamdi^{1

2}, Elaheh Mirhadi³, Wael Almahmeed⁴, Ali H Eid⁵, Khalid Al-Rasadi^{6

7}, Ninh T Nguyen⁸, Kishore M Gadde⁸, Amirhossein Sahebkar^{9

10

11}

Affiliations

¹ Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
² Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
⁵ Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
⁶ Medical Research Centre, Sultan Qaboos University, Muscat, Oman.
⁷ Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
⁸ Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA.
⁹ Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. amir_saheb2000@yahoo.com.
¹⁰ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.
¹¹ Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

PMID: 38743243
DOI: 10.1007/s13304-024-01866-8

Abstract

This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I²:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.

Keywords: Bariatric surgery; Irisin levels; Roux-en-Y gastric bypass; Sleeve gastrectomy.