Validation of the enhanced liver fibrosis (ELF)-test in heparinized and EDTA plasma for use in reflex testing algorithms for metabolic dysfunction-associated steatotic liver disease (MASLD)

Koen C van Son; Anne-Marieke van Dijk; Stan Driessen; Anne Linde Mak; Julia J Witjes; Veera A T Houttu; Diona Zwirs; Max Nieuwdorp; Bert-Jan H van den Born; Johan C Fischer; Maarten E Tushuizen; Joost P H Drenth; Henrike M Hamer; Ulrich H W Beuers; Joanne Verheij; Adriaan Georgius Holleboom

doi:10.1515/cclm-2024-0470

Validation of the enhanced liver fibrosis (ELF)-test in heparinized and EDTA plasma for use in reflex testing algorithms for metabolic dysfunction-associated steatotic liver disease (MASLD)

Clin Chem Lab Med. 2024 May 15. doi: 10.1515/cclm-2024-0470. Online ahead of print.

Authors

Koen C van Son^{1

2

3}, Anne-Marieke van Dijk^{1

2}, Stan Driessen^{1

2}, Anne Linde Mak¹, Julia J Witjes¹, Veera A T Houttu¹, Diona Zwirs¹, Max Nieuwdorp¹, Bert-Jan H van den Born^{1

4}, Johan C Fischer⁵, Maarten E Tushuizen⁶, Joost P H Drenth³, Henrike M Hamer⁵, Ulrich H W Beuers³, Joanne Verheij^{2

7}, Adriaan Georgius Holleboom¹

Affiliations

¹ Department of Vascular Medicine, 26066 Amsterdam UMC, Location AMC , Amsterdam, The Netherlands.
² 26066 Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Institute, Amsterdam UMC, Location AMC , Amsterdam, The Netherlands.
³ Department of Gastroenterology and Hepatology, 26066 Amsterdam UMC, Location AMC , Amsterdam, The Netherlands.
⁴ Department of Public and Occupational Health, 26066 Amsterdam UMC, Location AMC , Amsterdam, The Netherlands.
⁵ Laboratory Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
⁶ Department of Gastroenterology and Hepatology, LUMC, Leiden, The Netherlands.
⁷ Department of Pathology, 26066 Amsterdam UMC, Location AMC , Amsterdam, The Netherlands.

PMID: 38742657
DOI: 10.1515/cclm-2024-0470

No abstract available

Keywords: advanced liver fibrosis; diagnostic algorithms; enhanced liver fibrosis (ELF)-test; metabolic dysfunction-associated steatotic liver disease (MASLD); reflex testing.

Publication types

Letter