The digestion and dietary carbohydrate pathway contains 100% gene mutations enrichment among 117 patients with major depressive disorder

Ni Zhang; Jin Li; Zaiquan Dong; Yongbo Hu; Zhihui Zhong; Qiyong Gong; Weihong Kuang

doi:10.3389/fpsyt.2024.1362612

The digestion and dietary carbohydrate pathway contains 100% gene mutations enrichment among 117 patients with major depressive disorder

Front Psychiatry. 2024 Apr 29:15:1362612. doi: 10.3389/fpsyt.2024.1362612. eCollection 2024.

Authors

Ni Zhang¹, Jin Li¹, Zaiquan Dong¹, Yongbo Hu^{1

2}, Zhihui Zhong³, Qiyong Gong², Weihong Kuang^{1

4}

Affiliations

¹ Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China.
² Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
³ Laboratory of Non-human Primate Disease Modeling Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
⁴ National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Abstract

Introduction: Major depressive disorder (MDD) is partially inheritable while its mechanism is still uncertain.

Methods: This cross-sectional study focused on gene pathways as a whole rather than polymorphisms of single genes. Deep sequencing and gene enrichment analysis based on pathways in Reactome database were obtained to reveal gene mutations.

Results: A total of 117 patients with MDD and 78 healthy controls were enrolled. The Digestion and Dietary Carbohydrate pathway (Carbohydrate pathway) was determined to contain 100% mutations in patients with MDD and 0 mutation in matched healthy controls.

Discussion: Findings revealed in the current study enable a better understanding of gene pathways mutations status in MDD patients, indicating a possible genetic mechanism of MDD development and a potential diagnostic or therapeutic target.

Keywords: carbohydrate pathway; deep sequencing; gene mutation; major depressive disorder; reactome.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from National Key R&D Program of China (2022YFC2009906、2022YFC2009900), 1.3.5 Project of West China Hospital, Sichuan University (ZYJC21029), Post-Doctor Research Project, West China Hospital, Sichuan University (20HXBH040), and Project funded by China Postdoctoral Science Foundation(2021M692293).