The increasing global prevalence of the parasitic vector-borne disease leishmaniasis combined with rising resistance to current therapeutics necessitates the search for novel approaches to combat leishmania. This study evaluates the effects of novel strontium-based oxyfluorides for potential therapeutic use by testing cultures of Leishmania tarentolae, a species of Leishmania found in reptiles, as a model species. Cells were cultured with a range of mixed metal strontium oxyfluoride compounds selected to systematically test the relationship between compound structure and cell viability and enzyme activity over time.
Keywords: Anti-perovskites; Calcium; Gallium; Leishmania; Leishmania secreted proteases; Leishmaniasis; Oxyfluorides; Secreted acid phosphatases; Strontium.
© 2024 The Authors. Published by Elsevier Ltd.