Decennary Update on Oxidative-Rearrangement Involving 1,2-Aryl C-C Migration Around Alkenes: Synthetic and Mechanistic Insights

Ravinder Kumar

doi:10.1002/asia.202400053

Decennary Update on Oxidative-Rearrangement Involving 1,2-Aryl C-C Migration Around Alkenes: Synthetic and Mechanistic Insights

Chem Asian J. 2024 May 13:e202400053. doi: 10.1002/asia.202400053. Online ahead of print.

Author

Ravinder Kumar¹

Affiliation

¹ Maharishi Markandeshwar (Deemed to be University), Chemistry, Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana, 133207, Ambala, INDIA.

PMID: 38741472
DOI: 10.1002/asia.202400053

Abstract

In recent years, numerous methodologies on oxidative rearrangements of alkenes have been investigated, that produce multipurpose synthons and heterocyclic scaffolds of potential applications. The present review focused on recently established methodologies for oxidative transformation via 1,2-aryl migration in alkenes (2013-2023). Special emphasis has been placed on mechanistic pathways to understand the reactivity pattern of different substrates, challenges to enhance selectivity, the key role of different reagents, and effect of different substituents, and how they affect the rearrangement process. Moreover, synthetic limitations and future direction also have been discussed. We believe, this review offers new synthetic and mechanistic insight to develop elegant precursors and approaches to explore the utilization of alkene-based compounds for natural product synthesis and functional materials.

Keywords: 1,2-Aryl C-C Migration; Alkenes; Functionalized Ketones; Iodine and Metal-Catalyst; rearrangement.