Highly Efficient Self-Assembly of Heterometallic [2]Catenanes and Cyclic Bis[2]catenanes via Orthogonal Metal-Coordination Interactions

Qian Feng; Rui Ding; Yali Hou; Zeyuan Zhang; Yafei Zhang; Haifei Liu; Chenxing Guo; Gang He; Bo Zheng; Yanmin Zhang; Mingming Zhang

doi:10.1002/anie.202407923

Highly Efficient Self-Assembly of Heterometallic [2]Catenanes and Cyclic Bis[2]catenanes via Orthogonal Metal-Coordination Interactions

Angew Chem Int Ed Engl. 2024 May 13:e202407923. doi: 10.1002/anie.202407923. Online ahead of print.

Authors

Qian Feng¹, Rui Ding², Yali Hou³, Zeyuan Zhang³, Yafei Zhang³, Haifei Liu³, Chenxing Guo³, Gang He², Bo Zheng⁴, Yanmin Zhang⁵, Mingming Zhang⁶

Affiliations

¹ Xi'an Jiaotong University, State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, Xi'an, 710049, Xi'an, CHINA.
² Xi'an Jiaotong University, Frontier Institute of Science and Technology, CHINA.
³ Xi'an Jiaotong University, State Key Laboratory for Mechanical Behavior of Materials, Shaanxi International Research Center for Soft Matter, School of Materials Science and Engineering, CHINA.
⁴ Northwest University, Xi'an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry and Materials Science, CHINA.
⁵ Xi'an Jiaotong University, School of Pharmacy, Health Science Center, Xi'an, CHINA.
⁶ Xi'an Jiaotong Univeristy, School of Material and Science, No. 28 Xianning West Road, 710049, Xi'an, CHINA.

PMID: 38738617
DOI: 10.1002/anie.202407923

Abstract

Although catenated cages have been widely constructed due to their unique and elegant topological structures, cyclic catenanes formed by the connection of multiple catenane units have been rarely reported. Herein, based on the orthogonal metal-coordination-driven self-assembly, we prepare a series of heterometallic [2]catenanes and cyclic bis[2]catenanes, whose structures are clearly evidenced by single-crystal X-ray analysis. Owing to the multiple positively charged nature, as well as the potential synergistic effect of the Cu(I) and Pt(II) metal ions, the cyclic bis[2]catenanes display broad-spectrum antibacterial activity. This work not only provides an efficient strategy for the construction of heterometallic [2]catenanes and cyclic bis[2]catenanes but also explores their applications as superior antibacterial agents, which will promote the construction of advanced supramolecular structures for biomedical applications.

Keywords: antibacterial activities; catenanes; cyclic bis[2]catenanes; metal-coordination interactions; orthogonal self-assembly.