Dual stimuli-responsive upconversion nanoparticle-poly- N-isopropylacrylamide/DNA core-shell microgels

Qi Gao; Xiaowen Wang; Shanjin Hu; Ping-Ping He; Siyu Gou; Shuo Liu; Xiaoxue Du; Weiwei Guo

doi:10.1039/d4sm00258j

Dual stimuli-responsive upconversion nanoparticle-poly- N-isopropylacrylamide/DNA core-shell microgels

Soft Matter. 2024 May 22;20(20):4052-4056. doi: 10.1039/d4sm00258j.

Authors

Qi Gao¹, Xiaowen Wang¹, Shanjin Hu¹, Ping-Ping He¹, Siyu Gou¹, Shuo Liu¹, Xiaoxue Du^{1

2}, Weiwei Guo¹

Affiliations

¹ Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, P. R. China; Smart Sensing Interdisciplinary Science Center, School of Materials Science and Engineering, Nankai University, Tianjin 300350, P. R. China. weiweiguo@nankai.edu.cn.
² Handan Key Laboratory of Novel Nanobiomaterials, College of Materials Science and Engineering, Hebei University of Engineering, Handan 056000, P. R. China. duxiaoxue@hebeu.edu.cn.

PMID: 38738402
DOI: 10.1039/d4sm00258j

Abstract

Stimuli-responsive upconversion nanoparticle (UCNP)-poly-N-isopropylacrylamide (pNIPAM)/DNA core-shell microgels with tunable sizes and programmable functions have been prepared. Thanks to the near-infrared (NIR)-responsive UCNP cores and thermosensitive polymeric shells, functional DNA-incorporated microgels with high DNA activity and loading efficiency are obtained, and the activity of the loaded DNA structures can be smartly regulated by NIR illumination and temperature simultaneously.