Case report: [18F]FAPI-42 PET/CT visualize primary adenoid cystic carcinoma not detected by [18F]FDG

Zehao Wang; Zheng Liu; Lulu Zhuang; Weihua Yin; Yongsheng Zhao; Mengjie Dong

doi:10.62347/WSUV5599

Case report: [¹⁸F]FAPI-42 PET/CT visualize primary adenoid cystic carcinoma not detected by [¹⁸F]FDG

Am J Nucl Med Mol Imaging. 2024 Apr 25;14(2):157-160. doi: 10.62347/WSUV5599. eCollection 2024.

Authors

Zehao Wang^{1

2}, Zheng Liu¹, Lulu Zhuang^{3

2}, Weihua Yin⁴, Yongsheng Zhao¹, Mengjie Dong¹

Affiliations

¹ Department of Nuclear Medicine, Peking University Shenzhen Hospital Shenzhen, Guangdong, China.
² Shantou University Medical College Shantou, Guangdong, China.
³ Department of Medical Imaging, Peking University Shenzhen Hospital Shenzhen, Guangdong, China.
⁴ Department of Pathology, Peking University Shenzhen Hospital Shenzhen, Guangdong, China.

Abstract

Adenoid cystic carcinoma (ACC) is a rare salivary gland cancer. Still, its growth and invasion progress is slow, and its hematogenous metastasis is ACC's most common distant metastasis. Because of the broad expression and low background uptake of fibroblast activation protein (FAP) in tumor stroma, FAPI is considered another potential tracer of ACC in addition to FDG. In this case, we report a patient who was diagnosed with metastatic ACC liver cancer by fine needle aspiration biopsy (FNAB) and underwent PET/CT examination of [¹⁸F]FDG and [¹⁸F]FAPI-42 to find the primary cancer lesion. Finally, the primary cancer lesion was found in the left submandibular gland and was pathologically confirmed as ACC after resection.

Keywords: [18F]FAPI-42; [18F]FDG; adenoid cystic carcinoma; liver metastase.

Publication types

Case Reports