Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease

Ruiwei Guo; Jin Wu; Yanmin Zheng; Xiaona Lin; Zelin Zhuang; Jingjing Yin; Zhirong Lin; Lei Xie; Shuhua Ma

doi:10.2147/JIR.S462268

Graph Theory Further Revealed Visual Spatial Working Memory Impairment in Patients with Inflammatory Bowel Disease

J Inflamm Res. 2024 May 8:17:2811-2823. doi: 10.2147/JIR.S462268. eCollection 2024.

Authors

Ruiwei Guo^{1

2}, Jin Wu^{1

2}, Yanmin Zheng^{1

2}, Xiaona Lin^{1

2}, Zelin Zhuang^{1

2}, Jingjing Yin^{1

2}, Zhirong Lin¹, Lei Xie^{1

2}, Shuhua Ma^{1

2}

Affiliations

¹ Department of Radiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, People's Republic of China.
² Laboratory of Medical Molecular Imaging, The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, People's Republic of China.

Abstract

Background: Inflammatory Bowel Disease (IBD) patients may experience cognitive impairments in Visuospatial Working Memory (VSWM), significantly impacting their quality of life. However, the mechanisms underlying these impairments remain poorly understood.

Methods: We studied functional MRI and graph theory analysis to investigate changes in functional connectivity networks during the Mental Rotation Task (MRT) in IBD patients. Twenty IBD patients (13 males, 7 females; mean age = 34.95 ± 13.80 years; mean disease duration = 2.43 ± 2.37 years) participated in the study. Exclusion criteria encompassed recent use of analgesics, 5-Aminosalicylate, corticosteroids, or immunosuppressants within the past three months. Additionally, we recruited 20 age-, gender-, and education-matched healthy controls for comparison.

Results: Compared to a control group, IBD patients exhibited significantly longer reaction times and reduced accuracy during the MRT. Our analysis revealed abnormalities in multiple nodal attributes within the functional connectivity network, particularly in regions such as the bilateral orbitofrontal cortex, right supplementary motor area, bilateral parahippocampal gyrus, and bilateral anterior temporal lobe. We observed that the nodal efficiency in the left temporal pole is negatively correlated with Red Blood Cell Distribution Width (RDW) and positively correlated with response time of MRT.

Conclusion: Our findings revealed notable abnormalities in multiple node attributes among IBD patients during MRT, providing evidence of cognitive impairments in VSWM in IBD patients. This study found RDW maybe can serve as a clinical indicator for predicting early VSWM impairment in patients with IBD.

Keywords: cognitive impairment; graph theory; inflammatory bowel disease; mental rotation task; visuospatial working memory.

Grants and funding

This study was supported by the grants from the National Natural Science Foundation of China (GrantsNos.82004468, 82274657, and 81774395); the China Postdoctoral Science Foundation (Grants Nos. 2019M663021); the Natural Science Foundation of Guangdong Province (Grants No. 2019A1515011744); the Science and Technology Planning Project of Guangdong Province (Grants No.2017A020215060); the Medical Science and Technology Research Foundation of Guangdong Province of China (Grants No. B2020138); the Shantou Technology Bureau Science Foundation of China (Grants No. [2019] 106); and the Grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-level University Development Program (Grant No. 002-18120302).