Introduction:Corneal guttata is a non-inflammatory progressive decline of endothelial cell density (ECD) which represents an early clinical feature of Fuch's dystrophy. In patients with corneal guttata, the relative risk for corneal transplantation after phacoemulsification has been found to be 68.2 times higher than in those without it. In the present study, five patients with corneal guttata underwent 25G pars plana vitrectomy (PPV) with concurrent lensectomy and intraocular lens (IOL) implantation in the sulcus. The aim of the present study is to investigate whether this technique has a less damaging effect on endothelial cells as compared to standard phacoemulsification. Methods:This retrospective case series study was conducted at "My Retina" Athens Eye Centre, Greece. Five patients with moderate to dense cataract and clinical signs of corneal guttata were included. All patients had ECD measurement prior to and after surgery. The operation included 25-gauge pars plana vitrectomy (PPV) with subsequent lensectomy and a three-piece IOL implanted in the sulcus with intact anterior capsule. Results:The mean value of ECD was 1157.8±237.51 cells/mm² preoperatively and 1118.2±227.42 cells/mm² postoperatively, indicating a 3.4% reduction from initial values. Retinal detachment was not observed on any of the operated patients after surgery. The IOL was well centered to the sulcus in all patients. Iatrogenic retinal tears were identified in one patient and were treated with laser retinopexy and SF6 gas tamponade. Conclusion:Our results show that PPV along with lensectomy through fragmatome may cause less corneal decompensation than femtosecond laser-assisted cataract surgery (FLACS) or phacoemulsification, especially in patients with corneal guttata. Therefore, reducing the risk for possible future corneal transplantation.