Unveiling IL-17's role: Therapeutic insights and cardiovascular implications

Kexin Jiang; Yanjiani Xu; Yan Wang; Nanhao Yin; Fangyang Huang; Mao Chen

doi:10.1016/j.cytogfr.2024.05.001

Unveiling IL-17's role: Therapeutic insights and cardiovascular implications

Cytokine Growth Factor Rev. 2024 May 7:S1359-6101(24)00035-2. doi: 10.1016/j.cytogfr.2024.05.001. Online ahead of print.

Authors

Kexin Jiang¹, Yanjiani Xu², Yan Wang¹, Nanhao Yin³, Fangyang Huang⁴, Mao Chen⁵

Affiliations

¹ Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China.
² Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine, Sichuan University, Chengdu, China.
³ Division of Thoracic Tumor Multimodality Treatment, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
⁴ Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China. Electronic address: fyhuang1989@126.com.
⁵ Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, China. Electronic address: hmaochen@vip.sina.com.

PMID: 38735805
DOI: 10.1016/j.cytogfr.2024.05.001

Abstract

Interleukin-17 (IL-17), a pivotal cytokine in immune regulation, has attracted significant attention in recent years due to its roles in various physiological and pathological processes. This review explores IL-17 in immunological context, emphasizing its structure, production, and signaling pathways. Specifically, we explore its involvement in inflammatory diseases and autoimmune diseases, with a notable focus on its emerging implications in cardiovascular system. Through an array of research insights, IL-17 displays multifaceted functions yet awaiting comprehensive discovery. Highlighting therapeutic avenues, we scrutinize the efficacy and clinical application of four marketed IL-17 mAbs along other targeted therapies, emphasizing their potential in immune-mediated disease management. Additionally, we discussed the novel IL-17D-CD93 axis, elucidating recent breakthroughs in their biological function and clinical implications, inviting prospects for transformative advancements in immunology and beyond.

Keywords: Interleukin-17; cardiovascular disease; immune response.