Development and characterization of ZnxCuyTizMo alloys for biomedical applications: A high-throughput gradient continuous casting approach

Shang Dai; Luhai Liao; Muhammad Abubaker Khan; Yun Feng; Weili Yao; Jingyuan Li

doi:10.1016/j.actbio.2024.05.019

Development and characterization of Zn_xCu_yTi_zMo alloys for biomedical applications: A high-throughput gradient continuous casting approach

Acta Biomater. 2024 May 10:S1742-7061(24)00258-7. doi: 10.1016/j.actbio.2024.05.019. Online ahead of print.

Authors

Shang Dai¹, Luhai Liao², Muhammad Abubaker Khan¹, Yun Feng¹, Weili Yao¹, Jingyuan Li³

Affiliations

¹ Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
² School of Materials Science and Engineering, Hubei University of Automotive Technology, Shiyan 442002, China.
³ Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China. Electronic address: lijy@ustb.edu.cn.

PMID: 38735374
DOI: 10.1016/j.actbio.2024.05.019

Abstract

The limited mechanical properties of pure Zn, such as its low strength and ductility, hinder its application as a material for biodegradable implants. Addressing this challenge, the current study focuses on the development of biodegradable Zn-based alloys, employing innovative alloy design and processing strategies. Here, alloys with compositions ranging from 0.02 to 0.10 weight percent (wt%) Cu, 1.22 to 1.80 wt% Ti, and 0.04 to 0.06 wt% Mo were produced utilizing a high-throughput gradient continuous casting process. This study highlights three specific alloys: Zn_1.82Cu_0.10Ti_0.05Mo (HR8), Zn_0.08Cu_1.86Ti₀Mo (HR7), and Zn_1.26Cu_0.13Ti_0.06Mo (HR6), which were extensively evaluated for their microstructure, mechanical properties, electrochemical performance, potential as bioimplants, and cytotoxicity. These alloys were found to exhibit enhanced mechanical strength, optimal degradation rates, and superior biocompatibility, evidenced by in-vivo experiments with SD rats, positioning them as promising candidates for medical implants. This research not only introduces a significant advancement in biodegradable alloy development but also proposes an efficient method for their production, marking a pivotal step forward in biomedical engineering. STATEMENT OF SIGNIFICANCE: The limited mechanical properties of pure Zn have hindered its application in biodegradable implants. Our research primarily focuses on the alloy design and process strategies of biodegradable Zn-based alloys. We explore the ZnCu_xTi_xMo_x alloys. This study introduces a high-throughput experimental approach for efficient screening of multi-component alloy systems with optimal properties. The ZnCu_xTixMo_x alloys were designed and processed through gradient continuous casting, followed by homogenization and hot rolling. Our findings indicate that the Zn_1.82Cu_0.10Ti_0.05Mo alloy demonstrates superior tensile, mechanical, and corrosion properties post hot rolling. The study suggests that Zn_0.13Cu_1.26Ti_0.06Mo, Zn_0.08Cu_1.86Ti₀Mo, and Zn_1.82Cu_0.10Ti_0.05Mo alloys hold significant potential as biodegradable materials.

Keywords: Biodegradable alloys; Biomedical applications; High-throughput gradient continuous casting; Zn(x)Cu(y)Ti(z)Mo composition.