In vitro antibacterial activity of sulbactam-durlobactam in combination with other antimicrobial agents against Acinetobacter baumannii-calcoaceticus complex

Diagn Microbiol Infect Dis. 2024 Jul;109(3):116344. doi: 10.1016/j.diagmicrobio.2024.116344. Epub 2024 May 9.

Abstract

Combinations of the β-lactam/β-lactamase inhibitor sulbactam-durlobactam and seventeen antimicrobial agents were tested against strains of Acinetobacter baumannii in checkerboard assays. Most combinations resulted in indifference with no instances of antagonism. These results suggest sulbactam-durlobactam antibacterial activity against A. baumannii is unlikely to be affected if co-dosed with other antimicrobial agents.

Keywords: Acinetobacter baumannii-calcoaceticus complex; Checkerboard; Sulbactam-durlobactam.

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii* / drug effects
  • Acinetobacter calcoaceticus / drug effects
  • Anti-Bacterial Agents* / pharmacology
  • Azabicyclo Compounds* / pharmacology
  • Drug Combinations
  • Humans
  • Microbial Sensitivity Tests*
  • Sulbactam* / pharmacology
  • beta-Lactamase Inhibitors / pharmacology

Substances

  • Sulbactam
  • Azabicyclo Compounds
  • Anti-Bacterial Agents
  • durlobactam
  • beta-Lactamase Inhibitors
  • Drug Combinations