Metal organic framework-based polymeric hydrogel: A promising drug delivery vehicle for the treatment of breast cancer

Ishani Pandya; Sugam Kumar; Vinod K Aswal; Omar El Seoud; Mohammed A Assiri; Naved Malek

doi:10.1016/j.ijpharm.2024.124206

Metal organic framework-based polymeric hydrogel: A promising drug delivery vehicle for the treatment of breast cancer

Int J Pharm. 2024 May 10:658:124206. doi: 10.1016/j.ijpharm.2024.124206. Online ahead of print.

Authors

Ishani Pandya¹, Sugam Kumar², Vinod K Aswal², Omar El Seoud³, Mohammed A Assiri⁴, Naved Malek⁵

Affiliations

¹ Ionic Liquids Research Laboratory, Department of Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat 395007, Gujarat, India.
² Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
³ Institute of Chemistry, University of São Paulo, 05508-000 São Paulo, SP, Brazil.
⁴ Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
⁵ Ionic Liquids Research Laboratory, Department of Chemistry, Sardar Vallabhbhai National Institute of Technology, Surat 395007, Gujarat, India; Institute of Chemistry, University of São Paulo, 05508-000 São Paulo, SP, Brazil. Electronic address: navedmalek@chem.svnit.ac.in.

PMID: 38734276
DOI: 10.1016/j.ijpharm.2024.124206

Abstract

The constraints associated with current cancer therapies have inspired scientists to develop advanced, precise, and safe drug delivery methods. These delivery systems boost treatment effectiveness, minimize harm to healthy cells, and combat cancer recurrence. To design advanced drug delivery vehicle with these character, in the present manuscript, we have designed a self-healing and injectable hybrid hydrogel through synergistically interacting metal organic framework, CuBTC with the poly(vinyl alcohol) (PVA). This hybrid hydrogel acts as a localized drug delivery system and was used to encapsulate and release the anticancer drug 5-Fluorouracil selectively at the targeted site in response to the physiological pH. The hydrogel was formed through transforming the gaussian coil like matrix of PVA-CuBTC into a three-dimensional network of hydrogel upon the addition of crosslinker; borax. The biocompatible character of the hydrogel was confirmed through cell viability test. The biocompatible hybrid hydrogel then was used to encapsulate and studied for the pH responsive release behavior of the anti-cancer drug, 5-FU. The in vitro cytotoxicity of the drug-loaded hydrogel was evaluated against MCF-7 and HeLa cells. The study confirms that the hybrid hydrogel is effective for targeted and sustained release of anticancer drugs at cancer sites.

Keywords: Anti-cancer; CuBTC; Drug delivery; Hydrogel; Injectable; Metal organic frameworks.