Defining the subset of mutations in Polymerase Epsilon (POLE) associated with Loss-of-Proofreading (LOP) functionality

Affiliations

• ¹ Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, USA; Oncology Unit 1, Veneto Institute of Oncology-IRCCS, Padova, Italy; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padova, Italy.
• ² Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, USA.
• ³ Natera, Inc., Austin, TX.
• ⁴ Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Khalifa Institute for Personalized Cancer Therapy; The University of Texas MD Anderson Cancer Center, Houston, Texas; The Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
• ⁵ Department of Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, USA.
• ⁶ Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, USA. Electronic address: jshen8@mdanderson.org.