Spindle chirp and other sleep oscillatory features in young children with autism

Drew Cumming; Nataliia Kozhemiako; Audrey E Thurm; Cristan A Farmer; Shaun Purcell; Ashura W Buckley

doi:10.1016/j.sleep.2024.05.008

Spindle chirp and other sleep oscillatory features in young children with autism

Sleep Med. 2024 May 8:119:320-328. doi: 10.1016/j.sleep.2024.05.008. Online ahead of print.

Authors

Drew Cumming¹, Nataliia Kozhemiako², Audrey E Thurm¹, Cristan A Farmer¹, Shaun Purcell³, Ashura W Buckley¹

Affiliations

¹ National Institute of Mental Health, NIH, Bethesda, MD, USA.
² Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA. Electronic address: nkozhemiako@bwh.harvard.edu.
³ Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

PMID: 38733760
DOI: 10.1016/j.sleep.2024.05.008

Abstract

Objectives: To determine whether spindle chirp and other sleep oscillatory features differ in young children with and without autism.

Methods: Automated processing software was used to re-assess an extant set of polysomnograms representing 121 children (91 with autism [ASD], 30 typically-developing [TD]), with an age range of 1.35-8.23 years. Spindle metrics, including chirp, and slow oscillation (SO) characteristics were compared between groups. SO and fast and slow spindle (FS, SS) interactions were also investigated. Secondary analyses were performed assessing behavioural data associations, as well as exploratory cohort comparisons to children with non-autism developmental delay (DD).

Results: Posterior FS and SS chirp was significantly more negative in ASD than TD. Both groups had comparable intra-spindle frequency range and variance. Frontal and central SO amplitude were decreased in ASD. In contrast to previous manual findings, no differences were detected in other spindle or SO metrics. The ASD group displayed a higher parietal coupling angle. No differences were observed in phase-frequency coupling. The DD group demonstrated lower FS chirp and higher coupling angle than TD. Parietal SS chirp was positively associated with full developmental quotient.

Conclusions: For the first time spindle chirp was investigated in autism and was found to be significantly more negative than in TD in this large cohort of young children. This finding strengthens previous reports of spindle and SO abnormalities in ASD. Further investigation of spindle chirp in healthy and clinical populations across development will help elucidate the significance of this difference and better understand this novel metric.

Keywords: Autism”; “Chirp”; “Sleep”; “Slow oscillation”; “Spindle”.