Supported of gold nanoparticles on carboxymethyl lignin modified magnetic nanoparticles as an efficient catalyst for reduction of nitroarenes and treatment of human melanoma

Zunjiang Zhao; Dejin Wu; Dalun Lv; Xuan Zhang; Lei Chen; Baode Zhang

doi:10.1016/j.ijbiomac.2024.132250

Supported of gold nanoparticles on carboxymethyl lignin modified magnetic nanoparticles as an efficient catalyst for reduction of nitroarenes and treatment of human melanoma

Int J Biol Macromol. 2024 May 9;270(Pt 2):132250. doi: 10.1016/j.ijbiomac.2024.132250. Online ahead of print.

Authors

Zunjiang Zhao¹, Dejin Wu², Dalun Lv³, Xuan Zhang⁴, Lei Chen³, Baode Zhang²

Affiliations

¹ Department of Burns and Plastic Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241004, Anhui, China. Electronic address: Zhaozunjiang1974@163.com.
² Department of Burns and Plastic Surgery, Lu'an People's Hospital, Anhui Medical University, Lu'an 237005, Anhui, China.
³ Department of Burns and Plastic Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241004, Anhui, China.
⁴ Department of Burns and Plastic Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241004, Anhui, China; Department of Burns and Plastic Surgery, Lu'an People's Hospital, Anhui Medical University, Lu'an 237005, Anhui, China.

PMID: 38729467
DOI: 10.1016/j.ijbiomac.2024.132250

Abstract

This article represents the synthesis and characterizations of Au NPs immobilized and carboxymethyl lignin (CML) modified Fe₃O₄ nanoparticles (Fe₃O₄@CML/Au NPs) following a bio-inspired protocol without the participation of any toxic and harmful reductant or stabilizers. Following various physicochemical methodologies, such as FT-IR, FE-SEM, TEM, EDX, XRD, VSM, and ICP-OES, the textural characteristics and different structural aspects were evaluated. The Fe₃O₄@CML/Au NPs nanocomposite was subsequently explored towards the catalytic reduction of diverse aromatic nitro functions using green conditions. An excellent yield were achieved within very short reaction time. Nine recycling runs of the nanocatalyst were completed without a discernible loss of catalytic activity, thanks to its easy magnetic recovery. The DPPH assay was carried out to examine the antioxidant effectiveness. The Fe₃O₄@CML/Au NPs nanocomposite inhibited half of the DPPH in a 250 μg/mL solution. To measure the anti-human melanoma efficacy of Fe₃O₄@CML/Au NPs nanocomposite, MTT assay was applied on HT144, MUM2C, IPC-298 and SKMEL24 cell lines. Fe₃O₄@CML/Au NPs nanocomposite had high anti-human melanoma efficacy on above tumor cells. The best finding of anti-human melanoma properties of Fe₃O₄@CML/Au NPs nanocomposite was seen in the case of the SKMEL24 cell line. The IC₅₀ of Fe₃O₄@CML/Au NPs nanocomposite was 137, 145, 185, and 125 μg/mL against HT144, MUM2C, IPC-298 and SKMEL24 cells, respectively. This research exhibited remarkable anti-human melanoma and antioxidant efficacies of Fe₃O₄@CML/Au NPs nanocomposite in the in vitro condition.

Keywords: Carboxymethyl lignin; Fe(3)O(4)@CML/Au; Human melanoma; Nitro compounds; Reduction.