Ultrasensitive detection of chlortetracycline in animal-origin food using molecularly imprinted electrochemical sensor based on SnS2/ZnCo-MOF and AuNPs

Ruonan Sun; Shuang Han; Wei Zong; Hongtao Chu; Xunan Zhang; Haiyan Jiang

doi:10.1016/j.foodchem.2024.139537

Ultrasensitive detection of chlortetracycline in animal-origin food using molecularly imprinted electrochemical sensor based on SnS₂/ZnCo-MOF and AuNPs

Food Chem. 2024 May 6:452:139537. doi: 10.1016/j.foodchem.2024.139537. Online ahead of print.

Authors

Ruonan Sun¹, Shuang Han², Wei Zong¹, Hongtao Chu¹, Xunan Zhang¹, Haiyan Jiang¹

Affiliations

¹ College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China.
² College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China; Heilongjiang Provincial Key Laboratory of Catalytic Synthesis for Fine Chemicals, Qiqihar University, Qiqihar 161006, China. Electronic address: iamhanshuang1982@163.com.

PMID: 38728891
DOI: 10.1016/j.foodchem.2024.139537

Abstract

The chlortetracycline (CTC) residue in food poses a threat to human health. Therefore, developing sensitive, convenient and selective analytical methods for CTC detection is crucial. This study innovatively uses tin disulfide/bimetallic organic framework (SnS₂/ZnCo-MOF) nanocomposites in conjunction with gold nanoparticles (AuNPs) to co-modify a glassy carbon electrode (GCE). Further, a molecularly imprinted polymer (MIP)-based electrochemical sensing platform Au-MIP/SnS₂/ZnCo-MOF/Au/GCE (AZG) was fabricated for selective CTC detection. SnS₂/ZnCo-MOF enhanced the stability and surface area of the AZG sensor. The presence of AuNPs facilitated electron transport between the probe and the electrode across the insulating MIP layer. The fixation of AuNPs and MIP via electropolymerization enhanced the selective recognition of this sensor and amplified its output signal. The AZG sensor demonstrated a wide linear detection range (0.1-100 μM), low detection limit (0.072 nM), and high sensitivity (0.830 μA μM^-1). It has been used for detecting CTC in animal-origin food with good recovery (96.08%-104.60%).

Keywords: Animal-origin food; Au nanoparticles; Bimetallic organic frameworks; Chlortetracycline; Electrochemical sensor; Molecular imprinting.