Downregulation of SOX9 expression in developing entheses adjacent to intramembranous bone

PLoS One. 2024 May 10;19(5):e0301080. doi: 10.1371/journal.pone.0301080. eCollection 2024.

Abstract

Entheses are classified into three types: fibrocartilaginous, fibrous, and periosteal insertions. However, the mechanism behind the development of fibrous entheses and periosteal insertions remains unclear. Since both entheses are part of the temporomandibular joint (TMJ), this study analyzes the TMJ entheses. Here, we show that SOX9 expression is negatively regulated during TMJ enthesis development, unlike fibrocartilage entheses which are modularly formed by SCX and SOX9 positive progenitors. The TMJ entheses was adjacent to the intramembranous bone rather than cartilage. SOX9 expression was diminished during TMJ enthesis development. To clarify the functional role of Sox9 in the development of TMJ entheses, we examined these structures in TMJ using Wnt1Cre;Sox9flox/+ reporter mice. Wnt1Cre;Sox9flox/+ mice showed enthesial deformation at the TMJ. Next, we also observed a diminished SOX9 expression area at the enthesis in contact with the clavicle's membranous bone portion, similar to the TMJ entheses. Together, these findings reveal that the timing of SOX9 expression varies with the ossification development mode.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Down-Regulation
  • Fibrocartilage / metabolism
  • Mice
  • Mice, Transgenic
  • Osteogenesis* / genetics
  • SOX9 Transcription Factor* / genetics
  • SOX9 Transcription Factor* / metabolism
  • Temporomandibular Joint* / growth & development
  • Temporomandibular Joint* / metabolism

Substances

  • SOX9 Transcription Factor
  • Sox9 protein, mouse

Grants and funding

This study was supported by a grant for Assistance in Joint Research (20K10191: Masahito Yamamoto and 20K09895: Shinichi Abe) with the Community Program in Life Sciences from the Ministry of Education, Culture, Sports, Science and Technology of Japan Masahito Yamamoto: Conceptualization, Preparation of the manuscript, Data curation, Formal analysis, Investigation, Resources, Shinichi Abe: Project administration, Resources, Decision to publish.