Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes

Jovanka Ilic; Borislava Pujic; Branislava Jakovljevic; Borivoj Sekulic; Danijela Agic; Amir El Farra; Branimir Micanovic; Tihomir Vejnovic; Ivana Urosevic; Aleksandar Savic

doi:10.1002/ccr3.8900

Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes

Clin Case Rep. 2024 May 8;12(5):e8900. doi: 10.1002/ccr3.8900. eCollection 2024 May.

Authors

Jovanka Ilic¹, Borislava Pujic², Branislava Jakovljevic³, Borivoj Sekulic^{1

4}, Danijela Agic^{1

4}, Amir El Farra^{1

4}, Branimir Micanovic¹, Tihomir Vejnovic^{3

5}, Ivana Urosevic^{1

4}, Aleksandar Savic^{1

4}

Affiliations

¹ Clinic оf Hematology Clinical Center оf Vojvodina Novi Sad Serbia.
² Clinic of Anesthesia Intensive Care and Pain Therapy, Clinical Center оf Vojvodina Novi Sad Serbia.
³ Clinic of Gynecology and Obstetrics Clinical Center оf Vojvodina Novi Sad Serbia.
⁴ Department of Internal Medicine, Faculty оf Medicine University оf Novi Sad Novi Sad Serbia.
⁵ Department of Gynecology and Obstetrics, Faculty оf Medicine University оf Novi Sad Novi Sad Serbia.

Abstract

Paroxysmal nocturnal hemoglobinuria is a rare disease with the incidence ranging from 0.08 to 0.57 per 100,000 person-years. Up to 25% of cases in women are detected during pregnancy. We report two cases of successful pregnancy outcomes in patients treated with eculizumab, pointing out the importance of interdisciplinary approach in these high-risk pregnancies.

Keywords: PNH; eculizumab; paroxysmal nocturnal hemoglobinuria; pregnancy.

Publication types

Case Reports