Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima

Somporn Palasarn; Kitlada Srichomthong; Tuksaporn Thummarukcharoen; Chawanee Thongpanchang; Masahiko Isaka

doi:10.1038/s41429-024-00733-3

Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima

J Antibiot (Tokyo). 2024 May 9. doi: 10.1038/s41429-024-00733-3. Online ahead of print.

Authors

Somporn Palasarn¹, Kitlada Srichomthong¹, Tuksaporn Thummarukcharoen², Chawanee Thongpanchang¹, Masahiko Isaka³

Affiliations

¹ National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
² National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
³ National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand. isaka@biotec.or.th.

PMID: 38724629
DOI: 10.1038/s41429-024-00733-3

Abstract

Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC₅₀ values of 0.12 and 0.21 μM, respectively.

Grants and funding

N42A660851/National Research Council of Thailand (NRCT)