VACCINE ADHERENCE AND ADVERSE EVENTS OF THE SARS-COV VACCINE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Francisca Isabelle da Silva E Sousa; Raiza Lima Silva; Cezar Nilton Rabelo Lemos Filho; Maria Tereza Oliveira Pereira Santos; Luiz Eduardo Soares Martins; Thais Carvalho de Abreu; Leonardo Freire Alves Nogueira; Sâmya Correia Marques; Marcellus Henrique Loiola Ponte de Souza; Lucia Libanez Bessa Campelo Braga

doi:10.1016/j.gastrohep.2024.502202

VACCINE ADHERENCE AND ADVERSE EVENTS OF THE SARS-COV VACCINE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Gastroenterol Hepatol. 2024 May 7:502202. doi: 10.1016/j.gastrohep.2024.502202. Online ahead of print.

[Article in English, Spanish]

Affiliations

¹ School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
² Department of Internal Medicine, Federal University of Ceará, Walter Cantídio University Hospital, Fortaleza, CE, Brazil.
³ Department of Internal Medicine, Federal University of Ceará, Walter Cantídio University Hospital, Fortaleza, CE, Brazil. Electronic address: lucialib@terra.com.br.

PMID: 38723765
DOI: 10.1016/j.gastrohep.2024.502202

Abstract

Objective: to assess adherence to and the adverse effects of the SARS-COV vaccine in patients with Inflammatory Bowel Disease (IBD).

Patients and methods: This is an observational, analytical, cross-sectional study. Sociodemographic and clinical data, SARS-COV vaccine Data, medications for IBD with use during the vaccination period, and adverse events during the vaccination period were collected. Carried out Logistic regressions with robust variance estimation to estimate the Odds Ratio with the respective 95% Confidence Intervals (95%CI) to assess the factors associated with non-serious adverse effects following vaccine doses as outcome variables.

Results: 194 patients participated, with vaccine compliance of 78.3% for three doses of any vaccine (n=152). Local symptoms and mild systemic symptoms predominated, regardless of the type of vaccine. The first dose of the SARS-COV vaccine with AstraZeneca had a higher percentage of patients with vaccine symptoms. AstraZeneca vaccine increased the chance of non-serious adverse effects in IBD patients by 2.65 times (95% CI: 1.38-5.08; p=0.003), regardless of age, gender, physical activity, excess weight, use of disease-modifying drugs, immunobiological and corticosteroids. CoronaVac vaccine was associated with asymptomatic patients at the first dose and reduced the chance of adverse effects by 0.28 times (OR: 0.284; 95%CI: 0.13-0.62; p=0.002).

Conclusion: Local symptoms and mild systemic symptoms predominated, regardless of the type of vaccine. Using CoronaVac in the first dose reduced the chances of adverse effects, while AstraZeneca increased the risk of adverse effects.

Keywords: Adverse effects; Efectos adversos a largo plazo; Enfermedades Inflamatorias del Intestino; Inflammatory bowel disease; SARS-CoV 2; SARS-CoV-2; Vaccination; Vacunación.