Slings and arrows: sRNAs mediate intragenomic competition

Micah J Ferrell; Christopher M Waters

doi:10.1016/j.chom.2024.04.013

Slings and arrows: sRNAs mediate intragenomic competition

Cell Host Microbe. 2024 May 8;32(5):634-636. doi: 10.1016/j.chom.2024.04.013.

Authors

Micah J Ferrell¹, Christopher M Waters²

Affiliations

¹ Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.
² Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA. Electronic address: watersc3@msu.edu.

PMID: 38723602
DOI: 10.1016/j.chom.2024.04.013

Abstract

Bacterial genomes are littered with exogenous: competing DNA elements. Here, Sprenger et al. demonstrate that the Vibrio cholerae prophage VP882 modulates host functions via production of regulatory sRNAs to promote phage development. Alternatively, host sRNAs inhibit the VP882 lytic phase by specifically regulating phage genes.

MeSH terms

Bacteriophages / genetics
Bacteriophages / physiology
Gene Expression Regulation, Bacterial
Genome, Bacterial
Prophages* / genetics
Prophages* / physiology
RNA, Bacterial / genetics
RNA, Bacterial / metabolism
RNA, Small Untranslated / genetics
RNA, Small Untranslated / metabolism
Vibrio cholerae* / genetics

Substances

RNA, Small Untranslated
RNA, Bacterial