Brexpiprazole toxicity in a paediatric patient

BMJ Case Rep. 2024 May 6;17(5):e258561. doi: 10.1136/bcr-2023-258561.

Abstract

Brexpiprazole is a relatively new drug that has no published research or applications within the paediatric population. Brexpiprazole targets multiple receptors and can manifest as multisystem symptoms when ingested in supratherapeutic quantities. In this report, we discuss the case of a child in early childhood who presented with delayed neurological and cardiac symptoms 24 hours after accidental ingestion of brexpiprazole. Due to delayed onset, this case highlights that a high index of suspicion and prolonged observation are necessary to appropriately manage brexpiprazole overdose or accidental ingestion.

Keywords: Drugs: psychiatry; Medical management; Paediatrics (drugs and medicines); Poisoning; Toxicology.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects
  • Child, Preschool
  • Drug Overdose
  • Female
  • Humans
  • Male
  • Quinolones* / adverse effects
  • Quinolones* / poisoning
  • Thiophenes* / adverse effects

Substances

  • brexpiprazole
  • Thiophenes
  • Quinolones
  • Antipsychotic Agents