Autoantibodies against complement proteins in patients with antiphospholipid syndrome: Prevalence and clinical associations

Rémi Philip; Achille Aouba; Nicolas Martin Silva; Delphine Mariotte; Houcine Hamidi; Sanae Rhouni; Luc Darnige; Marie-Agnès Dragon-Durey

doi:10.1002/eji.202350832

Autoantibodies against complement proteins in patients with antiphospholipid syndrome: Prevalence and clinical associations

Eur J Immunol. 2024 May 3:e2350832. doi: 10.1002/eji.202350832. Online ahead of print.

Authors

Rémi Philip^{1

2

3}, Achille Aouba^{1

3}, Nicolas Martin Silva¹, Delphine Mariotte⁴, Houcine Hamidi^{2

5}, Sanae Rhouni⁵, Luc Darnige⁶, Marie-Agnès Dragon-Durey^{2

5}

Affiliations

¹ Department of Clinical Immunology and Internal Medicine, CHU of Caen Normandie, Caen, France.
² INSERM UMRS 1138 Team "Inflammation, Complement and Cancer", Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, France.
³ UNICAEN, CHU de Caen Normandie, Normandie University, Caen, France.
⁴ Laboratory of Immunology and Histocompatibility, Department of Biology, CHU of Caen Normandie, Caen, France.
⁵ Laboratory of Immunology, Hôpital Européen Georges-Pompidou, Assistance Publique Hopitaux de Paris (APHP), Paris, France.
⁶ Hematology Department, Hôpital Européen Georges-Pompidou, Assistance Publique Hôpitaux de Paris, Centre-Université de Paris (APHP-CUP), Université Paris Cité, Innovative Therapies in Haemostasis, INSERM UMR-S1140, Paris, France.

PMID: 38700064
DOI: 10.1002/eji.202350832

Abstract

Seventy-seven patients with antiphospholipid syndrome were tested for autoantibodies against C1q, C3, FB, FH, and C4bp. Fifty-seven patients had at least one anti-complement antibody. IgM anti-FH positivity was associated with thrombosis when anti-C3 and anti-FB were, negatively or positively, associated with various noncriteria manifestations of antiphospholipid syndrome.