Highlight of 2023: Unlocking the therapeutic potential of natural killer cells-advances in adaptive functions, cellular engineering and immunotherapy

Immunol Cell Biol. 2024 May 2. doi: 10.1111/imcb.12769. Online ahead of print.

Abstract

Natural killer (NK) cells possess potent cytotoxicity against infected and cancerous cells and hold promise in the development of new immunotherapies. This article for the Highlights of 2023 Series focuses on current advances in NK cell biology in cancerous and infectious settings and highlights opportunities for therapeutic interventions, including engineered NK cell therapies and advancements in feeder cell technologies.

Keywords: Adaptive functions; NK cells; cellular engineering; immunotherapy.