Hepatic PSMA-Avid Postradiation Inflammation

Clin Nucl Med. 2024 Jul 1;49(7):e373-e374. doi: 10.1097/RLU.0000000000005257. Epub 2024 May 2.

Abstract

A 62-year-old man with de novo large volume metastatic prostate cancer to the bone, liver, and nodes status post multiple lines of therapy including external beam radiation to T12-L2 approximately 13 months prior underwent 68 Ga-PSMA PET/CT to determine eligibility for 177 Lu-PSMA therapy. 68 Ga-PSMA PET/CT demonstrated tracer-avid osseous and nodal lesions consistent with metastases. In addition, regional geographic tracer avidity was seen in the midline left hepatic lobe associated with capsular retraction and demonstrated no FDG avidity on subsequent imaging, probably inflammatory related to prior radiation to T12-L2.

Publication types

  • Case Reports

MeSH terms

  • Antigens, Surface
  • Edetic Acid / analogs & derivatives
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Glutamate Carboxypeptidase II / metabolism
  • Humans
  • Inflammation* / diagnostic imaging
  • Liver / diagnostic imaging
  • Male
  • Middle Aged
  • Oligopeptides
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms* / diagnostic imaging
  • Prostatic Neoplasms* / pathology
  • Prostatic Neoplasms* / radiotherapy

Substances

  • Gallium Radioisotopes
  • Gallium Isotopes
  • gallium 68 PSMA-11
  • Edetic Acid
  • Oligopeptides
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II
  • Antigens, Surface