A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution

Shitong Huang; Jevon W Marsh; Jhanelle R G White; Tracy Q Ha; Sophie A Twigger; Ismael Diez-Perez; Adam C Sedgwick

doi:10.1039/d4nj00859f

A colorimetric approach for monitoring the reduction of platinum(iv) complexes in aqueous solution

New J Chem. 2024 Apr 10;48(17):7548-7551. doi: 10.1039/d4nj00859f. eCollection 2024 Apr 29.

Authors

Shitong Huang¹, Jevon W Marsh¹, Jhanelle R G White², Tracy Q Ha², Sophie A Twigger³, Ismael Diez-Perez², Adam C Sedgwick^{1

2}

Affiliations

¹ Chemistry Research Laboratory, University of Oxford Mansfield Road OX1 3TA UK adam.sedgwick@kcl.ac.uk.
² Department of Chemistry, King's College London 7 Trinity Street London SE1 1DB UK.
³ Department of Oncology, University of Oxford Old Road Campus Research Building Oxford OX3 7DQ UK.

Abstract

We report the synthesis of 4-nitrophenyl (4-NP) functionalised Pt(iv) complexes as a colorimetric strategy for monitoring Pt(iv) reduction in aqueous solution. Treatment of each 4-NP functionalised Pt(iv) complex with the biological reductant sodium ascorbate led to a colour change from clear to yellow, which was attributed to the reduction of Pt(iv) to Pt(ii) and simultaneous release of 4-nitroaniline. Trends in reduction profiles and a photocatalysed reduction for each Pt(iv) complex were observed.