Proteomics appending a complementary dimension to precision oncotherapy

Zhaokai Zhou; Ruiqi Zhang; Aoyang Zhou; Jinxiang Lv; Shuang Chen; Haijiao Zou; Ge Zhang; Ting Lin; Zhan Wang; Yuyuan Zhang; Siyuan Weng; Xinwei Han; Zaoqu Liu

doi:10.1016/j.csbj.2024.04.044

Proteomics appending a complementary dimension to precision oncotherapy

Comput Struct Biotechnol J. 2024 Apr 20:23:1725-1739. doi: 10.1016/j.csbj.2024.04.044. eCollection 2024 Dec.

Authors

Zhaokai Zhou^{1

2}, Ruiqi Zhang¹, Aoyang Zhou¹, Jinxiang Lv³, Shuang Chen⁴, Haijiao Zou⁴, Ge Zhang⁵, Ting Lin¹, Zhan Wang², Yuyuan Zhang¹, Siyuan Weng¹, Xinwei Han^{1

6

7}, Zaoqu Liu^{1

6

7

8}

Affiliations

¹ Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
² Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China.
³ Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
⁴ Center of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
⁵ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
⁶ Interventional Institute of Zhengzhou University, Zhengzhou, Henan 450052, China.
⁷ Interventional Treatment and Clinical Research Center of Henan Province, Zhengzhou, Henan 450052, China.
⁸ Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Abstract

Recent advances in high-throughput proteomic profiling technologies have facilitated the precise quantification of numerous proteins across multiple specimens concurrently. Researchers have the opportunity to comprehensively analyze the molecular signatures in plentiful medical specimens or disease pattern cell lines. Along with advances in data analysis and integration, proteomics data could be efficiently consolidated and employed to recognize precise elementary molecular mechanisms and decode individual biomarkers, guiding the precision treatment of tumors. Herein, we review a broad array of proteomics technologies and the progress and methods for the integration of proteomics data and further discuss how to better merge proteomics in precision medicine and clinical settings.

Keywords: Data integration; Molecular typing; Precision oncotherapy; Protein network; Proteomics; Proteomics analysis technology.

Publication types

Review