Redefining the concept of residual renal function with kidney sodium MRI: a pilot study

Sandrine Lemoine; Alireza Akbari; Gary Brahm; Justin Dorie; Tanya Tamasi; Jarrin Penny; Christopher W McIntyre

doi:10.1093/ndt/gfae070

Redefining the concept of residual renal function with kidney sodium MRI: a pilot study

Nephrol Dial Transplant. 2024 Apr 30:gfae070. doi: 10.1093/ndt/gfae070. Online ahead of print.

Authors

Sandrine Lemoine^{1

2

3}, Alireza Akbari^{3

4

5}, Gary Brahm⁶, Justin Dorie³, Tanya Tamasi³, Jarrin Penny^{3

5}, Christopher W McIntyre^{3

4

5

7}

Affiliations

¹ Hospices Civils de Lyon, Néphrologie-HTA-Dialyse et exploration fonctionnelle rénale, Hôpital Edouard Herriot, Lyon, France.
² Univ Lyon, CarMeN Laboratory, IRIS Team, INSERM, INRA, INSA Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France.
³ Lilibeth Caberto Kidney Clinical Research Unit, University of Western Ontario, London, Ontario, Canada.
⁴ Robarts Research Institute, Western University, London, Canada.
⁵ Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
⁶ Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
⁷ Division of Nephrology, London Health Sciences Centre, London, Ontario, Canada.

PMID: 38688870
DOI: 10.1093/ndt/gfae070

Abstract

Rationale & objective: The concept of residual kidney function (RKF) is exclusively based upon urine volume and small solute clearance, making RKF challenging to assess in clinical practice. The aim of this study was to test the technical feasibility of obtaining useable 23Na-MRI kidney images in hemodialysis (HD) participants.

Study design: We conducted an exploratory prospective study to quantify the cortico-medullary sodium gradient in healthy and HD participants. Participants fasted for eight hours prior to their study visit. Urine samples were collected to measure urinary osmolarity, before MRI. Proton and sodium pictures were merged; ROIs were delineated for the medulla and cortex when feasible. In cases where cortex could not be identified, we considered the cortico to medulla gradient (CMG) to be no longer present, resulting in a medulla-to-cortex ratio of 1.

Setting & participants: 17 healthy volunteers and 21 HD participants.

Findings: Median (IQR) fasting medulla to cortex ratio was significantly higher 1.56 [1.5-1.61] in healthy volunteers compared to HD patients 1.22 [1.13-1.3], p < 0.0001. Medulla to cortex ratio and median urinary osmolarity were correlated (r = 0.87, p < 0.0001) in the whole population. We found a significant association between HD vintage and medulla to cortex ratio whereas we did not find any association with urine volume. Sodium signal intensity distribution within healthy kidney describes two different peaks- relating to well defined cortex and medulla; whereas HD participants displays only a single peak indicative of the markedly lower sodium concentration.

Limitations: This study is only an exploratory study with a modest number of patients.

Conclusions: the application of kidney sodium MRI to the study of RKF in patients receiving maintenance HD is practical and provides a previously unavailable ability to interrogate the function of remnant tubular function.

Keywords: Magnetic Resonance Imaging; corticomedularry gradient; haemodialysis; kidney residual function; sodium.