Fabrication of polysaccharide-coated oleanolic acid-curcumin-coassembled nanoparticles (OA/Cur NPs): Enhancement of colloidal stability and water solubility

Linlin Yan; Han Liu; Yuhui Wang; Lulu Zhang; Chao Ma; A M Abd El-Aty

doi:10.1016/j.foodchem.2024.139482

Fabrication of polysaccharide-coated oleanolic acid-curcumin-coassembled nanoparticles (OA/Cur NPs): Enhancement of colloidal stability and water solubility

Food Chem. 2024 Apr 25:451:139482. doi: 10.1016/j.foodchem.2024.139482. Online ahead of print.

Authors

Linlin Yan¹, Han Liu², Yuhui Wang², Lulu Zhang², Chao Ma³, A M Abd El-Aty⁴

Affiliations

¹ Institute of Chemical Industry of Forest Products, CAF; Key Lab. of Biomass Energy and Material, Jiangsu Province; Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration; National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing 210042, China.
² Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China.
³ Beijing Key Laboratory of Forest Food Processing and Safety, College of Biological Science and Technology, Beijing Forestry University, Beijing 100083, China. Electronic address: machao@bjfu.edu.cn.
⁴ Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, Erzurum 25240, Turkey.

PMID: 38688096
DOI: 10.1016/j.foodchem.2024.139482

Abstract

Natural terpenoid carriers, such as oleanolic acid (OA), can enhance the water solubility and stability of hydrophobic compounds such as curcumin (Cur). However, improving the colloidal stability of nanoparticle emulsions and resolving the redispersion problem of freeze-dried nanoparticle powders remain significant challenges. In this study, we fabricated coassembled oleanolic acid-curcumin nanoparticles (OA/Cur NPs) and applied a polysaccharide surface coating method to improve their colloidal stability and water solubility. The results showed that the optimal ratio of Cur/OA for preparing OA/Cur NPs was 4:10, resulting in a high encapsulation efficiency (EE) of Cur (75.2%). Additionally, TEM, contact angle tests, Turbiscan TOWER optical stability analysis of the polysaccharide-coated OA/Cur NP emulsions and redispersion tests of their lyophilized powders verified the advantages of carboxymethyl chitosan/β-cyclodextrin (CMC/β-CD) coating over other polysaccharides. This study indicated that polysaccharide coating is an effective method for enhancing the colloidal stability, water solubility, and redispersibility of OA/Cur NPs.

Keywords: Colloidal stability; Curcumin; Nanoparticle; Oleanolic acid; Polysaccharides; Surface coating.