Specific antigens in malignancy-associated membranous nephropathy

Xiaoying Hu; Guoqin Wang; Hong Cheng

doi:10.3389/fmed.2024.1368457

Specific antigens in malignancy-associated membranous nephropathy

Front Med (Lausanne). 2024 Apr 15:11:1368457. doi: 10.3389/fmed.2024.1368457. eCollection 2024.

Authors

Xiaoying Hu¹, Guoqin Wang¹, Hong Cheng¹

Affiliation

¹ Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Abstract

Membranous nephropathy (MN) is a glomerular disease mediated by autoimmune complex deposition, with approximately 30% of cases attributed to secondary causes. Among them, malignant tumors are a significant cause of secondary MN. Recent advancements in the identification of MN-specific antigens, such as THSD7A and NELL-1, suggest a potential association with malignant tumors, yet definitive proof of this relationship remains elusive. Therefore, this article aims to review the distribution of MN-specific antigens in patients with MN caused by malignant tumors and the possible role of these antigens in the pathogenesis of the disease.

Keywords: NELL-1; PLA2R; THSD7A; malignant tumor; membranous nephropathy.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of Beijing grant 7192050 and Capital’s Funds for Health Improvement and Research (2022-2-2066).