Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review

Roshani Patil; Sanjay Sharma

doi:10.2174/0113895575293447240424052516

Chemistry, Analysis, and Biological Aspects of Daprodustat, A New Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor: A Comprehensive Review

Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575293447240424052516. Online ahead of print.

Authors

Roshani Patil¹, Sanjay Sharma¹

Affiliation

¹ Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS; Deemed to be University, Vile Parle West, Mumbai, Maharashtra 400056, India.

PMID: 38685804
DOI: 10.2174/0113895575293447240424052516

Abstract

Background: The National Health and Nutrition Examination Survey (NHANES) carried out a survey between 2007-10 and found that as compared to the general population, the prevalence of anemia in chronic kidney disease (CKD) patients was twice high. Daprodustat is an investigational novel drug for the treatment of renal anemia.

Objective: The objective of this study is to provide a comprehensive review of chemistry, synthesis, pharmacology, pharmacokinetic, and bioanalytical methods for the analysis of Daprodustat.

Methods: To improve understanding, a review was carried out by creating a database of relevant prior research from electronic sources such as ScienceDirect and PubMed. The methodology is shown in the flowchart of the literature selection process.

Results: The drug was approved in 2020 for therapeutic purposes in Japan. It is a novel drug approved for the treatment of anemia in chronic kidney disease for oral administration. It is intended for adults who have undergone dialysis for a minimum of four months and are experiencing anemia as a result of chronic kidney disease.

Conclusion: This review examines therapeutic, pharmacological, and analytical aspects related to the novel drug Daprodustat.

Keywords: Daprodustat; analytical analysis of daprodustat; anemia.; chemical properties of daprodustat; pharmacology of daprodustat; synthesis of daprodustat.