Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders

Xiaoling Chen; Ting Lu; Ying Zheng; Zhiyong Lin; Chaoqi Liu; Ding Yuan; Chengfu Yuan

doi:10.2174/0109298673283936240215110627

Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders

Curr Med Chem. 2024 Apr 27. doi: 10.2174/0109298673283936240215110627. Online ahead of print.

Authors

Xiaoling Chen^{1

2}, Ting Lu^{1

2}, Ying Zheng^{1

2}, Zhiyong Lin^{1

2}, Chaoqi Liu^{1

2}, Ding Yuan³, Chengfu Yuan^{2

4}

Affiliations

¹ Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, China Three Gorges University, Yichang, 443002, China.
² College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
³ College of Medicine and Health Science, China Three Gorges University, Yichang, 443002, China.
⁴ Third Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, School of Medicine, Yichang, 443002, China.

PMID: 38685774
DOI: 10.2174/0109298673283936240215110627

Abstract

Background: MiR-136-5p plays a vital function in regulating developmental processes as well as in the pathophysiology of diseases, with a notable record in tumor suppression.

Methods: This article summarizes the latest findings on the physiological and pathophysiological processes of miR-136-5p in diseases. We searched for relevant studies and selected research articles from the last five years on PubMed with miR-136-5p as the keyword.

Results: MiR-136-5p represents a class of microRNAs (miRNAs) that are involved in various human maladies, encompassing cancers, cardio-cerebrovascular disease, diabetes, inflammatory disease, tuberous sclerosis, idiopathic pulmonary fibrosis, and polycystic ovary syndrome. Altered expression of miR-136-5p in specific ailments results in downstream gene expression imbalance, influencing cellular behaviors, such as migration, proliferation, and invasion. Furthermore, miR-136-5p is implicated in five signaling pathways, where it is critical in the onset and advancement of a number of illnesses. Additionally, it has the potential to promote drug resistance to a variety of medications.

Conclusion: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.

Keywords: MiR-136-5p; bioinformatics; cancer; cell.; inflammation; signaling pathway.