Mechanisms of Heavy Metal Cadmium (Cd)-Induced Malignancy

Hairong Wang; Xuehui Gan; Yan Tang

doi:10.1007/s12011-024-04189-2

Mechanisms of Heavy Metal Cadmium (Cd)-Induced Malignancy

Biol Trace Elem Res. 2024 Apr 29. doi: 10.1007/s12011-024-04189-2. Online ahead of print.

Authors

Hairong Wang¹, Xuehui Gan¹, Yan Tang²

Affiliations

¹ School of Public Health, Southwest Medical University, No. 1, Section 1, Xianglin Road, Longmatan District, Luzhou, 646000, China.
² School of Public Health, Southwest Medical University, No. 1, Section 1, Xianglin Road, Longmatan District, Luzhou, 646000, China. tangyan200310@163.com.

PMID: 38683269
DOI: 10.1007/s12011-024-04189-2

Abstract

The environmental pollution of cadmium is worsening, and its significant carcinogenic effects on humans have been confirmed. Cadmium can induce cancer through various signaling pathways, including the ERK/JNK/p38MAPK, PI3K/AKT/mTOR, NF-κB, and Wnt. It can also cause cancer by directly damaging DNA and inhibiting DNA repair systems, or through epigenetic mechanisms such as abnormal DNA methylation, LncRNA, and microRNA. However, the detailed mechanisms of Cd-induced cancer are still not fully understood and require further investigation.

Keywords: Cadmium; DNA damage; Epigenetic; Heavy metals; Malignancy; Signaling pathways.

Publication types

Review

Abstract

Publication types

Grants and funding