Symptomatic Hyponatremia due to Tacrolimus-Induced Salt-Losing Nephropathy in a Kidney Transplant Recipient

Abstract

Tacrolimus is the most important drug in current posttransplant immunosuppressive protocol. Salt-losing nephropathy causing symptomatic hyponatremia as an adverse effect of tacrolimus has been rarely reported. We report recurrent hyponatremia and graft dysfunction in a young renal transplant recipient, with no evidence of rejection, attributable to. tacrolimus-induced salt-wasting nephropathy.

Keywords: Calcineurin toxicity; kidney transplant; salt-losing nephropathy; tacrolimus-induced hyponatremia.