Paracentral acute middle maculopathy in a patient with Myelin Oligodendrocyte glycoprotein antibody associated optic neuritis

Aniruddh Heroor; Mudit Tyagi; Ramesh Kekunnaya; Goura Chattannavar

doi:10.1016/j.ajoc.2024.102058

Paracentral acute middle maculopathy in a patient with Myelin Oligodendrocyte glycoprotein antibody associated optic neuritis

Am J Ophthalmol Case Rep. 2024 Apr 19:34:102058. doi: 10.1016/j.ajoc.2024.102058. eCollection 2024 Jun.

Authors

Aniruddh Heroor¹, Mudit Tyagi², Ramesh Kekunnaya³, Goura Chattannavar³

Affiliations

¹ Standard Chartered Academy of Eye Care Education, L V Prasad Eye Institute, Hyderabad, India.
² Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, India.
³ Jasti V Ramanamma Children's Eye Care Centre, Child Sight Institute, L V Prasad Eye Institute, Hyderabad, India.

Abstract

Purpose: There is insufficient literature reporting the concurrent occurrence of retinal ischemic lesions with optic neuritis. In this case report, we present a distinctive instance of Optic Neuritis with a positive Myelin Oligodendrocyte glycoprotein (MOG) antibody, accompanied by retinal ischemia manifesting as paracentral acute middle maculopathy (PAMM) lesions.

Observations: Our patient is a 25-year-old female who tested positive for MOG antibodies and exhibited retinal PAMM lesions without any apparent underlying ischemic cause. She received intravenous pulse steroid therapy, and her symptoms and signs completely resolved one month later.

Conclusion: PAMM can serve as an initial manifestation of Myelin Oligodendrocyte glycoprotein Antibody Associated Disease (MOGAD). This case has the potential to contribute to the existing literature, facilitating a deeper exploration of the pathophysiology of retinal ischemia in MOG associated optic neuritis.

Keywords: Myelin oligodendrocyte glycoprotein (MOG); Optic neuritis; Paracentral acute middle maculopathy(PAMM).

Publication types

Case Reports